Synergize Men

Formula Ingredient Deck

Benefits Of Each Ingredient 

Vitamin A (beta carotene)

•  May support vision health, skin health, immune health, and increases antioxidant support (182, 183).

• May support antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased L-glutathione production (master antioxidant) (182, 183).

• May support visual health via increased amounts of plasma vitamin A in macular (eye) tissues (182,183).

Vitamin C

• May support immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).

• May support immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).

• May support fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).

• May support accelerated bone healing after a fracture, increased type I collagen synthesis, and reduced oxidative stress (inflammation) (98).

Calcium Carbonate

•  May support bone health, muscle function, and cardiovascular health (36,37).

•  Regulates processes of bone resorption, mineralization, and fracture repair (36,37).

• Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37). 

• May support reduced prevalence of preeclampsia (36,37).

Vitamin D3

• May support exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance,  increased strength, and positive mood (77,78,79).

• May support hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone based negative feedback loop reactions (77,78).

• May support cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77,78).

• May support exercise recovery via reduced post exercise inflammation and muscle damage (77,78).

• May support sexual health via increased activity of Vitamin D receptor activity of testosterone production (79).

• May support immune function via decreases of inflammatory cytokines and aiding immune cells (77,78).

• May support joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77,78).

Vitamin E

• May support immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208)

• May support immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204).

• May support cardiovascular health via reduced cholesterol (204).

• May support cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208).

Vitamin B1 (Thiamine)

• May support aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).

• May support cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95). 

Vitamin B2 (Riboflavin)

• May support conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93).

Vitamin B3 (Niacin)

• Major B vitamin that may support cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).

• Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).

• Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).

• May support healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).

• May support reduced prevalence of pellagra, nervous anorexia, and Crohn’s disease (10, 11).

Vitamin B6

• Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).

• May support reduced plasma glucose (blood sugar levels) via inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).

• Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).

• May support blood sugar regulation in women with gestational diabetes (40).

• Cofactor for enzymes involved in DNA metabolism (40).

Vitamin B12

• May support  proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53).

• Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).

• May support  reduced  vitamin b-12 deficiency pathologies such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).

Zinc

• May support immune function, skin health, cognitive function, and vision (172,173).

• May support stimulation of the innate and adaptive immune system (172,173).

• May support the activation of lymphocytes and activation of innate  T cell-mediated immunity (172,173).

• May support cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173). 

Biotin

• May support conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214).

• May support glucose breakdown into skeletal muscle tissue (213,214).

Vitamin B5

• May support energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).

Magnesium

• May support optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91).

• Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91).

• May support reduced systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91).

• May support reduced peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91).

Copper

• May support healthy blood sugar levels, energy metabolism and cholesterol management (143,144).

Selenium

• May support antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146).

• May support reduced prevelance of atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147).

• May support thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146).

• Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increases natural killer activity, and increases glutathione (master antioxidant) levels (145,147).

Manganese

• May support enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148,149).

Molybdenum 

• May support increased enzymatic reactions involved in sulfite metabolism and detoxification (150).

Chromium

• May support insulin function, reduced cholesterol, improved blood sugar regulation, and may lower cholesterol (218,219).

Lutein 

• A carotenoid that may support vision health, immune health, cardiovascular health, and combats diabetic retinopathy (155,156).

• May support increased lutein concentration in the macula and exhibits various features such as anti-inflammatory, anti-oxidative, and blue light-filtering effects (155,156).

• May support visual health via increased lutein concentration in the macular layer of the retina, reduced susceptibility to age-related macular disease, reduced prevalence of cataracts, and improved plasma level of lutein and retinal macular pigment level (155,156).

Lycopene

• May support prostate health, cardiovascular support, antioxidant, anti-inflammatory, and chemoprotective properties against cancer (191,192, 193).

• May support reduced inflammation via scavenging of free radicals and reduces oxidative damage of DNA. (191,192,193).

• Inhibits phosphorylation of anti-oncogenes such as p53 and Rb. It also inhibits G0/G1 and S-phase of the cell cycle (193).

Spirulina

• May support reduced cholesterol, blood pressure, blood sugar regulation, reduces inflammation, reduced body fat, and supports antioxidant function (301, 302).

Goldenseal Root

• May support digestive health, antibacterial activity, and antioxidant support (201, 202). 

• May support antioxidant function via increased levels of berberine (alkaloid) (201,202).

Echinacea

• May support immune health via increased antiviral, anti-microbial, antioxidant capacity, (159,160).

• May support immune health via decreased impro-inflammatory markers (cytokines IL-6, IL-8, and TNF) (159,160). 

• May support adaptive and innate immunity via increased monocytes, neutrophils, natural killer cells, and CD8 T cells (159,160).

Garlic

• May support cardiovascular health, immune health, joint health, reduced inflammation, gut health, and enhanced antibacterial activity (161).

• May support cardiovascular health via reduced hypertension, reduced total cholesterol, reduced arterial stiffness (hardening of arteries), and markers of atherosclerosis (161).

• May support joint health via reduced NF-κB activation (inflammation) in human fibroblasts cells and reduced prevalence of pain in individuals with rheumatoid arthritis (162).

• May support gut health via increased prebiotic properties, increased microbiome population, and increased Lactobacillus and Clostridia species (163).
  
  

• May support immune health via a reduction in inflammatory markers (CRP, TNF, IL-6) (164). 

Green Tea Extract

•  A potent polyphenolic antioxidant that may support blood pressure, insulin sensitivity, and metabolic health (25).

• High in ECGC (epigallocatechin gallate) (25).

• ECGC is shown to reduce body fat mass, increase fat oxidation(burning) and increase caloric expenditure during exercise. (25).

• Potent anti-inflammatory compound that may support glutathione production and inhibition of pro-inflammatory markers (cytokines). (26).

• May support reduced oxidative stress (chronic inflammation in the body) (26).

Hawthorn Berries

• May support cardiovascular health and combats metabolic syndrome (165).

• May support cardiovascular health via reduced atherosclerotic lesion areas, reduced cholesterol synthesis (acyl-coA-cholesterol acyltransferase enzyme), reduced very-low-density lipoproteins (VLDL), and inhibited platelet aggregation (165). 

Cinnamon Bark Extract

• May support blood sugar regulation and cardiovascular health (166).

• May support decreased levels of fasting plasma glucose, total cholesterol, LDL-C, triglyceride levels, and an increase in HDL-C levels (166).

• May support improved blood sugar regulation by improving insulin sensitivity and enhanced glucose uptake (166).

Bilberry Fruit Extract

• May support vision health, cardiovascular function, increased nitric oxide production, blood sugar regulation, and antioxidant support (167,168).

Grape Seed Extract

• May support increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31).

• May support antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31).

• May support cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

Black Currant

• May support immune function via high levels of polyphenols and reduction of inflammation (169).

• May support cardiovascular health via reductions in LDL Cholesterol (169).

Pomegranate Extract

• May support reduced blood pressure, increased nitric oxide production, immune health, blood sugar regulation, prostate health, gut health and aids as an antimicrobial compound (170).

• May support prostate health via high polyphenolic antioxidant levels (three times the antioxidant activity of green tea) that protect the prostate gland from inflammation (170).

• May support reduced blood pressure via increased nitric oxide production, increased cardiac output (blood flow), and reduced cholesterol levels (170.

• May support digestive health via combating inflammatory bowel disease (171).

• May support immune health via reduced inflammatory cytokines (markers of inflammation) throughout the body (171).