Insynerate - All Day Fat Burning

Freeman Formula INSYNERATE is a metabolic optimizer and can be best categorized as a caloric wasting and fat burning compound . Whereas most fat burning formulations on today's market depend on stimulants such as ephedra (rarely seen today), caffeine, and synephrine at Freeman Formula, we reject the premise that the only effective way to burn fat is to "stimulate" the body into submission. While stimulants do increase metabolic rate, they also increase the production of catabolic (muscle wasting) hormones such as cortisol. As cortisol levels rise in the body, lean muscle tissue is broken down, immune system function is suppressed and dangerous abdominal belly fat deposition is increased. Stimulants also decrease natural production of epinephrine and nor epinephrin (two of the bodies main neurotransmitters) as well as decreasing Beta receptors that help block or release fat storage. 

It is important to know that the quantity of lean muscle in the body is highly correlated with the basal metabolic rate (BMR). Less muscle means a lower BMR! If stimulant- based fat burners are used to help shed unwanted body fat, there's a very good chance that, once they are discontinued, metabolic rate will be significantly lower and the predisposition to gain unwanted body fat will be significantly higher.

If this scenario wasn't bad enough, consider that stimulants raise blood pressure, increase heart rate, and increase anxiety levels. Therefore, individuals with a history of heart disease, high blood pressure, or brain chemistry abnormalities should certainly steer clear of these compounds. Stimulant fat burners work initially but ultimately will decrease the bodies ability to burn fat. 
In the following paragraphs, I will explain how the unique herbal compounds in this formula work in synergy to create the extremely potent, non-stimulant based, fat burner/ metabolic optimizer that we find in Freeman Formula INSYNERATE

T2 (3,5 di-iodo-thyronine) 

T2 is a metabolite of the thyroid hormones T4 (thyroxine) & T3 (triiodothyronine). It has specific direct actions which do not involve thyroid hormone receptors, unlike T4 and T3. 
(1) It raises BMR (basal metabolic rate) which in turn increases energy expenditure in
the body. 

(2) It's a metabolic uncoupling agent that "uncouples" or disconnects the ATP-producing machinery in the cell and "releases" all the potential energy that was supposed to be used to produce ATP. Due to the energy and ATP loss (which is dissipated as heat), the muscle cells must dig into stored body fat stores and oxidize additional fats to ensure
that optimal energy levels are maintained. It is VERY important to consume adequate amounts of complete proteins to insure an increased nitrogen balance so that the increased energy expenditure does not deplete and break down muscle tissue. 

The following analogy should help explain how T2 exerts its energy-wasting effect in the human body. Imagine someone putting a hole in the gas tank of your automobile. The
car would still perform at maximal capacity however, it would require a significant
amount of additional fuel to travel the same distance it had prior to the punctured tank. Likewise, T2 makes the mitochondrial membranes more permeable (creates openings) which cause the loss of valuable "fuel" (ATP) from the "tank" (muscle cell). To combat
this energy loss, additional fatty acids ( FAT) must be oxidized and used as energy to ensure optimal performance levels. 

Even more exciting is that fact that T2 "wastes" calories without elevating blood
pressure, without raising heart rate, and without causing central nervous system over- stimulation. 

(3)T2 stimulates the conversion of T4 (inactive thyroid hormone) into the more active T3 form. 

(4)T2 stimulates the release of growth hormone (GH) which is a powerful fat burning
and tissue regenerating compound.

Inside the cell, L-carnitine transports long chain fats into the mitochondria (energy- producing chamber) where they are then oxidized into ATP. In theory, if we can increase the amount of L-carnitine within the muscle, we can theoretically increase the quantity of fatty acids that get oxidized. Until recently the problem has been that regular L-carnitine and even the more exotic acetyl-L-carnitine lacked the ability to penetrate skeletal muscle tissue (which is where most fat oxidation occurs). 

On the other hand, Propionyl-L-carnitine, a relatively new version of L-carnitine, has important effects on skeletal and cardiac muscle. Back in 1990, a human study demonstrated that propionyl-L-carnitine could combat the destructive effects of low oxygen status and muscle fatigue in heart and skeletal muscle. More relevant is the fact that propionyl-L-carnitine has a tremendous ability to penetrate skeletal muscle and thus facilitate the transport of long chain fatty acids into the mitochondria to be used as energy. 

GUGGULSTERONES 

The thyroid gland releases a hormone known commonly as thyroxin (T4 for short). T4 is an inactive form of thyroid hormone that must ultimately be converted into triiodothyronine (T3), the active thyroid hormone. Whenever any sort of diet is initiated, (less food is consumed) the body's natural inclination is to slow down the conversion of T4 (inactive) to T3 (active). Ultimately, when this happens, metabolic rate slows and fat losses crawl to a halt. 

In India, the Guggul is a tree which exudes a resinous sap out of incisions that are made in its bark. This resin has been used for centuries as part of Indias traditional medicine called Ayurveda. This resinous sap can be processed, purified, and then standardized for its active components Guggulsterones Z and Guggulsterones E. These two fractionations have the unique ability to support thyroid function by increasing the conversion of inactive T4 into active T3 and, in doing so, restore normal thyroid function to the repetitive dieter or dieting athlete.

PIPER BETLE LEAF and DOLICHOS BIFLORUS SEED

Piper betle leaf helps to increase Adiponectin (fat burning hormone), and Dolichos biflorus seed help to decrease Ghrelin hormon that makes you hungry. 

Adiponectin is the hormone that tells your body to burn fat for fuel. The more of this super hormone you have circulating in your bloodstream, the more fat you burn. Low levels of adiponectin are associated with higher levels of obesity. And elevated levels of adiponectin are not only associated with increased fat catabolism (i.e., fat burning), but also increased insulin sensitivity.

Additionally, adiponectin helps reduce insulin resistance. Insulin resistance is responsible for most blood sugar issues and something that makes it impossible to lose weight even when following a low calorie diet. 
The frustrating thing about adiponectin is that the more fat you have, the lower your adiponectin levels. This is why LOSING fat not just weight is so difficult at the beginning for many people..
It turns out that one of the best ways to increase adiponectin is to reduce the levels of your stress hormone cortisol. 

Ghrelin is known as the Hunger Hormone. Basically the more ghrelin you have in your system, the hungrier you are. 
So if you find yourself fighting cravings and cant seem to stay away from the fridge after dinner, it is probably due to elevated ghrelin levels. 
Ghrelin inhibits serotonin release making you feel unsatisfied and hungry which increases food intake and increases fat storage.

Even worse, ghrelin activates the reward link in your brain for things like sweet, fatty foods, and even alcohol and cigarettes. 
You can see why losing fat is almost impossible with elevated levels of ghrelin! Cortisol increase from stess or adrenal fatigue also causes elevated ghrelin levels. 
High ghrelin has also been shown to decrease the thyroid hormones (T3 & T4) slowing the metabolic process. 

INSYNERATE is a very potent and powerful metabolic optimizer. It helps the body to utilize more energy and burn more calories. 
INSYNERATE forces the body to use fat as its energy source. All this while blocking fat storage.